Metabolism inMycobacterium leprae:possible targets for drug action
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Evolutionary conservation of drug action on lipoprotein metabolism-related targets.
Genetic analysis has shown that the slower than normal rhythmic defecation behavior of the clk-1 mutants of Caenorhabditis elegans is the result of altered lipoprotein metabolism. We show here that this phenotype can be suppressed by drugs that affect lipoprotein metabolism, including drugs that affect HMG-CoA reductase activity, reverse cholesterol transport, or HDL levels. These pharmacologic...
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The identification of new antibacterial targets is urgently needed to address multidrug resistant and latent tuberculosis infection. Sulfur metabolic pathways are essential for survival and the expression of virulence in many pathogenic bacteria, including Mycobacterium tuberculosis. In addition, microbial sulfur metabolic pathways are largely absent in humans and therefore, represent unique ta...
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ژورنال
عنوان ژورنال: Leprosy Review
سال: 1986
ISSN: 0305-7518
DOI: 10.5935/0305-7518.19860109